The field of PROTACs and hypoxia-activated therapies is rapidly evolving, and there may have been significant developments since my last update. I recommend consulting recent scientific literature, research papers, or reaching out to experts in the field for the most up-to-date information on the current state of hypoxia-activated PROTAC development.1
References
1Bhole RP, Kute PR, Chikhale RV, Bonde CG, Pant A, Gurav SS. Unlocking the potential of PROTACs: A comprehensive review of protein degradation strategies in disease therapy. Bioorganic Chemistry. 2023;139:106720. doi:10.1016/j.bioorg.2023.106720